The 20 worst epidemics and pandemics in history

Plagues and epidemics have ravaged humanity throughout its existence, often changing the course of history.

1. Prehistoric epidemic: Circa 3000 B.C.
2. Plague of Athens: 430 B.C.
3. Antonine Plague: A.D. 165-180
4. Plague of Cyprian: A.D. 250-271
5. Plague of Justinian: A.D. 541-542
6. The Black Death: 1346-1353
7. Cocoliztli epidemic: 1545-1548
8. American Plagues: 16th century
9. Great Plague of London: 1665-1666
10. Great Plague of Marseille: 1720-1723
11. Russian plague: 1770-1772
12. Philadelphia yellow fever epidemic: 1793
13. Flu pandemic: 1889-1890
14. American polio epidemic: 1916
15. Spanish Flu: 1918-1920
16. Asian Flu: 1957-1958
17. AIDS pandemic and epidemic: 1981-present day
18. H1N1 Swine Flu pandemic: 2009-2010
19. West African Ebola epidemic: 2014-2016
20. Zika Virus epidemic: 2015-present day